PHYSOSTIGMINE ANTAGONISM OF MORPHINE-INDUCED RESPIRATORY DEPRESSION
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چکیده
منابع مشابه
Antagonism of morphine-induced respiratory depression with nalmefene.
The duration of respiratory depression induced by morphine 10 mg/70 kg was studied following the administration of one of two opioid antagonists. Respiratory measurements included: (i) the ventilatory response to carbon dioxide, described in two ways--the minute ventilation at an end-tidal carbon dioxide partial pressure of 8 kPa (VE8) and the log slope of the ventilatory response to carbon dio...
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The ability of physostigmine to antagonize the respiratory depressant effect of morphine was studied in conscious rabbits and ketamine-anaesthetized dogs pretreated with atropine methyl nitrate. Morphine 4 mg kg-1 increased PaCO2 in the rabbit from 3.43 +/- 0.16 to 4.95 +/- 0.28 kPa, decreased arterial pH from 7.45 +/- 0.01 to 7.31 +/- 0.01 and decreased respiratory frequency by 36%. Physostigm...
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Morphine is often used in cancer pain and postoperative analgesic management but induces respiratory depression. Therefore, there is an ongoing search for drug candidates that can antagonize morphine-induced respiratory depression but have no effect on morphine-induced analgesia. Acetylcholine is an excitatory neurotransmitter in central respiratory control and physostigmine antagonizes morphin...
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on ketamine requirement. Following atropine premedication ketamine 5 mg lb" was administered i.m. They found that i.v. supplementation was required to prevent limb movement before surgery in 70% of patients less than 1 year of age and showed that i.v. ketamine requirements for surgical anaesthesia were associated with age, weight and surface area, age being most significant: i.v. ketamine (ng l...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1981
ISSN: 0007-0912
DOI: 10.1093/bja/53.9.1006